CoVal

CoVal is a repository of amino acid replacement mutations identified in the SARS-CoV-2 genome sequences, mapped onto the cryo-EM derived protein structures. We provide information on the demographic distribution of these mutations, and report co-occuring mutations. Upon mapping these mutations, we inspect the mutation site for its structural interactions and neighbors. We further provide various validation scores for global quality of the structures, and the local quality of mutation site(s) and the structural neighbors.


Mutations in SARS-CoV2

BROWSE Browse mutations
1 / 10
Spike N501Y
2 / 10
Nsp12 P323L
3 / 10
Nuc-prot R203K
4 / 10
Nuc-prot G204R
5 / 10
ORF3a Q57H
6 / 10
Spike A222V
7 / 10
Spike S477N
8 / 10
Spike N439K
9 / 10
Spike E583Q
10 / 10
Spike E484K



  • UK variant Spike mutations (N501Y,A570D,P681H,T716I,S982A,D1118H)

  • UK Spike mutation (N501Y)
  • UK Spike mutation site N501Y in structure bound to ACE2 receptor
  • Other resources

    GISAID Global initiative on sharing all influenza data and coronavirus responsible for Covid-19
    CoVGLUE A database of amino acid replacements, insertions and deletions observed in GISAID hCoV-19 sequences sampled from the pandemic
    Structure Taskforce Public resource for the structures from beta-coronavirus with a focus on SARS-CoV and SARS-CoV-2
    Covid19 data portal A shared data space that brings together and continuously updates relevant COVID-19 datasets (submitted to EMDB-EBI and partners) and tools
    Nextstrain Global and continental level analysis of SARS-Cov2 genome data
    EMDataResource Collection of coronavirus structures from EMDataResource


    Last update 2021-01-13 using GISAID version: hcov-19-2021-01-08

    Note that this is an alpha release: still undergoing development and testing